The test was invented by a Greek physiologist named Georgios Papanicolaou. He was born on the island of Evia on the 13th May 1883. He attended the University of Munich and achieved his PhD in zoology in 1910. He then eloped with the woman he would spend the next 47 years of his life with, Andromache Mavroyeni, who went by Mary. The two returned to Greece in 1912, where Georgios served in the Balkan Wars. Following this, he and Mary immigrated to New York City in 1912.
Although initially playing violin in restaurants to pay the bills, Georgios quickly found work at Cornell Medical College slowly rising up the ranks. It was here that he made the observation that eventually led to the pap smear.